The blood types must be compatible to avoid an ABO incompatibility reaction.For example: Type O blood does not cause an immune response when it is given to people with type A, type B, or type AB blood.This is why type O blood cells can be given to patients of any blood type.

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The types are based on small substances (molecules) on the surface of the blood cells.

When people who have one blood type receive blood from someone with a different blood type, it may cause their immune system to react. People who have one blood type may form proteins (antibodies) that cause their immune system to react against one or more of the other blood types.

Being exposed to another type of blood can cause a reaction.

This is important when a patient needs to receive blood (transfusion) or have an organ transplant.

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